Security on the web has taken a new dimension with AJAX-driven websites. AJAX-driven websites are more susceptible to cross-site scripting (XSS) attacks and offer easier means of call and logic discovery.
I had covered these in sessions titled "Building Secure Next Generation Web Applicaitons" during the recent Security Yatra and also during some MSDN Days organized in a few SIs in India.
Some of the really startling attacks I discovered while preparing the content for the demo included the MySpace worm. The complete details are available at http://namb.la/popular/
Not only did the worm bypass all of Myspace.com's rules, but surprised the author of the malicious code himself by affecting a million users in under 20 hours!
I just also received an email that talks about a very interesting vulnerability in PDF and Adobe Reader that makes it possible to perform serious XSS attacks. That was quite startling because the avenues are increased not just to AJAX-sites but common technology such as Adobe PDF and OpenOffice. The article is available at http://www.eweek.com/article2/0,1895,2079201,00.asp?kc=EWEWEMNL010107EP26A
The actual attack instructions are also available here. But let me warn you not to try this with any site. Don't mess around - it is a dangerous world out there.
And for all your developers there, if that didn't shake you and say "Take security seriously", I don't know what will.