I am very moved by "Uncle Petros and the Goldbach Conjecture" by Apostolos Doxiadis. It's a work of fiction that makes several references to real people and real mathematics. It seems the author has done a fair bit of research to write this book. The book is about a mathematician "Uncle Petros" who spends his entire life trying to prove the Goldbach Conjecture.
In the course of the book, Doxiadis touches on the lives of G H Hardy, S. Ramanujan, Cantor, Kurt Godel and much of the pain, isolation, failure and achievement that is involved in doing research. The book is a fascinating read and is in many ways very true to life though the main characters are fictious.
The Goldbach Conjecture simply states that every even number greater than 2 can be expressed as the sum of two primes. Wikipedia has some more detail. The conjecture has been known for about 250 years now. There is still no proof, though the fact has been verified for very large numbers. It is a conjecture and not a theorem because it has no proof. Work still continues on this. Dare to try solve it? You may also enjoy looking at the Goldbach weave.
In the early 90's a long standing famous problem, Fermat's Last Theorem was proved by Andrew Wiles. It took him 7 years of exclusive work to prove the theorem. The theorem has been know since 1637! And has escaped all these centuries without proof despite many many mathematicians working on it. One of the things that made Fermat's last theorem famous is that Fermat has scribbled in the margin of his notebook a comment to the effect that he knew a proof but that the margin is not wide enough to note it. (Wikipedia) Wiles's proof is 150 pages and uses mathematics discovered in the 20th century - this is most likely not the proof that Fermat had in mind, if indeed he had a correct proof.
The interesting things about proofs like these are not just that they confirm the truth of statements that we always suspected to be true, but that they advance the state of mathematics. In the course of chasing hard problems, often new theories and new approaches to proof theory are discovered.